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- W2367742703 abstract "Objective To compare the p16 dynamic status in primary hepatocellular carcinoma(HCC) and its metastatic lesions.Methods The exon 2 of p16 gene was examined by PCR SSCP analysis in 36 paraffin embedded samples in 18 primary HCC cases and its metastatic lessions. Results p16 alterations were found in 4 (22.2%) of the 18 patients . Among them, 2 patients had alterations only in the metastatic lesions (one was deletion;the other was mutation).The other 2 patients had alterations both in primary and metastatic loci (one was deletion;the other was mutation).The deletion rate of exon 2 was 11.1%(2/18) and the mutation rate was 11.1%(2/18). However,the four alterations of p16 gene were found in 7 patients whose metastasis was accompanied by HCC recurrence ( 57.1% ), which was significantly higher than that in patients with metastasis but without HCC recurrence (P 0.05 ). In 4 patients with p16 gene alteration,they had significantly earlier postoperative recurrence and metastasis (an average of 7 months) than the other 14 patients without p16 gene alteration (an average of 21 months)(P 0.05 ).Conclusions The alterations of p16 gene play an important role in the recurrence and metastasis of HCC. And some alterations of p16 gene may start in the metastatic lesions." @default.
- W2367742703 created "2016-06-24" @default.
- W2367742703 creator A5089449978 @default.
- W2367742703 date "2003-01-01" @default.
- W2367742703 modified "2023-09-23" @default.
- W2367742703 title "Comparison of p16 status in primary hepatocellular carcinoma and its metastasis" @default.
- W2367742703 hasPublicationYear "2003" @default.
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