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- W2367744395 abstract "Objective To investigate the influence of astragalus on the number,activity,and inducible nitric oxide synthase(iNOS) of peripheral endothelial progenitor cells (EPCs). Methods Total mononuclear cells (MNCs) were isolated from peripheral blood by Ficoll density gradient centrifugation,and then the cells were inoculated on fibronectin-coated culture dishes. After 7 days of culturing,attached cells were stimulated with astragalus solution (in a series of final concentrations of 10,20,50 and 100 g/L)for 24 hours. Meanwhile,the attached cells in the control group and astragalus 50 g/L group were cultured for 6,12,24,48 h respectively. EPCs were identified by laser confocal microscopy and were counted under inverted fluorescence microscope. The proliferation and migration of EPCs were assayed with MTT assay and modified Boyden chamber assay,respectively. EPCs adhesion assay was performed by re-inoculation of EPCs on fibronectin-coated dishes,and then adherent cells were counted. In vitro vasculogenesis activity of EPCs was assayed by in vitro vasculogenesis kit. iNOS was assayed by western blot. Results Incubation of isolated human MNCs with astragalus increased the number of EPCs,as well as their proliferative,migratory,adhesive and invitro vasculogenesis capacity in a concentration and time dependent manner. Astragalus also increased iNOS content of EPCs. Conclusion Astragalus increases the number of EPCs,and enhances the proliferative,migratory,adhesive and in vitro vasculogenesis capacity of EPCs. Its mechanism is related to the increase of iNOS by astragalus." @default.
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- W2367744395 date "2007-01-01" @default.
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- W2367744395 title "Effects of Astragalus on Number and Activity of Peripheral Endothelial Progenitor Cells" @default.
- W2367744395 hasPublicationYear "2007" @default.
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