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- W2367746124 abstract "Objective: To evaluate the involvement of Angiotensin-converting enzyme(ACE),Angiotensinogen(AGT) and endothelial nitric oxide synthase(eNOS) gene polymorphisms in predisposition to coronary heart disease(CHD) as well as their possible synergetic effect in the development of CHD.Method: The study included 287 subjects(133 with CHD and 154 controls).Gene chip technology was performed.The allele frequency and genotype distribution were compared between groups.Result: Significantly higher frequencies of the DD genotype of ACE gene,TT genotypes of AGT and eNOS gene were observed in CHD group.The ACE,AGT and eNOS gene polymorphisms were associated with CHD(OR=2.17,P0.01,OR=2.63,P0.001,OR=8.50,P0.05,respectively).Subjects carrying ACE DD and AGT TT genotype or those carrying AGT TT and eNOS TT genotype showed a stronger association with CHD(OR=3.47,P0.01,OR=1.05,P0.01,respectively).Conclusion: The ACE,AGT and eNOS gene polymorphisms may be risk factors of CHD in China.Gene chip technology provides an effective and sensitive method to study the relationship of gene polymorphisms and CHD." @default.
- W2367746124 created "2016-06-24" @default.
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- W2367746124 date "2006-01-01" @default.
- W2367746124 modified "2023-09-24" @default.
- W2367746124 title "The Research of AC Angiotensinogen and Endothelial Nitric Oxide Synthase gene Polymorphisms in Predisposition to CHD with Gene Chip Technology" @default.
- W2367746124 hasPublicationYear "2006" @default.
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