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- W2367769413 abstract "Objective To investigate the effect of local treatment with Zoledronate acid on osseointegration of dental implants in osteoporotic rats.Methods 30 female rats were randomly divided into three groups: sham(A group),ovariectomized(B group) and zoledronate-treated(C group) groups.Animals in group B and C received bilateral ovariectomy,while in group A underwent sham-operation.12 weeks after surgery,femoral bones of rats were examined for bone mineral density(BMD) to verify osteoporosis status.Then bone defects were made at the proximal metaphyses of tibiae and placement of hydroxyapatite(HA) coated titanium implants(group A and B) or Zoledronate acide immobilized HA-implants(group C),were performed.Animals were killed at 4 and 12 weeks after implant surgery and undercalcified sections were prepared and examined histologically and histomorphometrically.Results At 4 and 12 week after implantation surgery,implant-bone contact rate(IBCR) and new bone volume(NBV) in group B were all significantly decreased compared to group A and C(P0.01);while the bone indices(IBCR,NBV) in group C were similar with those of group A(P0.05).Conclusions Experimental osteoporosis can decrease IBCR,while local application treatment with Zoledronate acid may resist the negative influence of osteoporosis and promote bone graft healing and osseointagration of dental implants." @default.
- W2367769413 created "2016-06-24" @default.
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- W2367769413 date "2012-01-01" @default.
- W2367769413 modified "2023-09-25" @default.
- W2367769413 title "Effect of local treatment with Zoledronate acid on osseointegration of dental implants in osteoporotic rats" @default.
- W2367769413 hasPublicationYear "2012" @default.
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