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- W2367769742 abstract "Objective: To investigate the effects of N-acetylcysteine (NAC) on the intestinal barrier in a rat model of car-diopulmonary bypass (CPB). Methods: Eighteen SD rats weighing 300～400 g were randomly divided into three groups which included control group (group S), group CPB (group C) and group CPB plus NAC (group A) (100 mg/kg into cardiopulmonary bypass prime followed by infusion at 20 mg·kg-·1h-1 )with 6 animals in each group. The rat model of CPB was established. The samples of gut tissues and plasma were collected at 2 h after CPB. Plasma levels of diamine oxidase (DAO) activity, D-lactate concentrations, lipopolysaccharide (LPS) level and microscopy of intestinal mucosa were studied . Results: Compare with group S, Plasma DAO activity, D-lactate concentration and LPS level were significantly increased in group C and A (P 0.05). Plasma DAO activity, D-lactate concentration and LPS level in group A were much lower than those in group C (P 0.05). NAC significantly attenuated the damage to the intestinal mucosa ultramicrostructure. Conclusion: Treatment with NAC sig-nificantly decreased plasma D-lactate concentration, LPS level and DAO activity. NAC has a crucial protective role in intesti-nal mucosal barrier during CPB." @default.
- W2367769742 created "2016-06-24" @default.
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- W2367769742 date "2009-01-01" @default.
- W2367769742 modified "2023-09-26" @default.
- W2367769742 title "Effects of N-acetylcysteine on the Gut Mucosal Barrier Function in Rat Cardiopulmonary bypass Model" @default.
- W2367769742 hasPublicationYear "2009" @default.
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