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- W2367770432 abstract "Objectives: To explore the effects of zaofukang on enzymatic activities of DNA topoisomerases (TOPO)and its direct effect on DNA Methods: The activity of TOPO I was measured by TOPO I mediated supercoiled pBR322 relaxation The activity of TOPO II was evaluated by TOPO II mediated kDNA decatenation Direct DNA breakages were determined by supercoiled pBR322 and kDNA Results: The TOPO I mediated DNA relaxations were completely inhibited by the water soluble component and the DMSO soluble component of zaofukang at the concentrations of 3 2 μg/ml and 80 μg/ml respectively The two components completely inhibited TOPO II mediated kDNA decatenation at the concentrations of 16 μg/ml and 2000 μg/ml respectively Furthermore, the water soluble component induced DNA breakage directly at a high concentration of 10 mg/ml Conclusion: These results suggest that topoisomerases, mainly TOPO I, would be one of thecellular targets of zaofukang" @default.
- W2367770432 created "2016-06-24" @default.
- W2367770432 creator A5074943236 @default.
- W2367770432 date "2000-01-01" @default.
- W2367770432 modified "2023-09-23" @default.
- W2367770432 title "Inhibition of DNA topoisomerases and direct DNA breakage by extract of spirulina plantensis geitl" @default.
- W2367770432 hasPublicationYear "2000" @default.
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