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- W2367770669 abstract "Objective According to pharmacodynamics and toxic action,an anti-epileptic principle with high efficacy and low toxicity was selected from six kinds of extracts from root of Stellera chamaejasme L.,so as to benefit the preclinical survey of its pharmacological mechanism.Methods Median effective doses (ED 50) for experimental epilepsy of the six kinds of extracts from radix stellerae were determined among three kinds of experimental epileptic models.And their median lethal doses (LD 50) were counted during 24 hours.Results Extracts Ⅲ,Ⅳ,Ⅴ and Ⅵ were able to antagonize maximal electroshock seizure (MES),metrazol seizure test (MET) in mouse,and also elevate threshold for localized seizure by direct cortical stimulation in rat.Among these four kinds of extracts,extract Ⅲ had a low toxicity,and therapeutic index (TI=LD 50/ED 50) high up to 14.9.Conclusion Extract Ⅲ from radix stellerae becomes a hopeful and valuable anti-epileptic herbal medicine." @default.
- W2367770669 created "2016-06-24" @default.
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- W2367770669 date "2004-01-01" @default.
- W2367770669 modified "2023-09-26" @default.
- W2367770669 title "A screening study on radix stellerae extracts to combat experimental epilepsy in animal model" @default.
- W2367770669 hasPublicationYear "2004" @default.
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