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- W2367773721 abstract "[Objectives] To investigate the protective effect of Veratrum nigrum L.Var.ussurience Nakai alkaloids(VnA) on cardiac hypertrophy induced by Isoproterenol(ISO) in mices.[Methods] Therapy group were given VnA i.v.6 hours before ISO treatment.Then we invertigated the cardiac weight index and the MDA content,the activity of SOD and Ca2+-ATPase in myocardium,myocardiac morphological alterations were observed by pathological section and transmission electron microscope.[Results] VnA of the high dose and middle dose were effective to decrease the cardiac weight index and MDA content [the high dose group is(2.39±0.48) nmol·mg-1 prot,VS the model group(3.56±1.08) nmol·mg-1 prot,P0.01],improve the activity of SOD [the high dose group is(131.32±20.07) nmol·mg-1 prot,VS the model group(107.43±7.86) nmol·mg-1 prot,P0.05)] and Ca2+-ATPase in myocardium [the high dose group is(5.78±0.51) μmolpi·mgprot-1·h-1,VS the model group(4.06±0.38) μmolpi·mgprot-1·h-1,P0.01];VnA improved the left ventricular tissue morphological alteration.[Conclusions] VnA possess protective effects against Isoproterenol that induced cardiac hypertrophy in mices and dose-depent from 15~45 μg/kg.This may be related to reducing the oxidative stress,activating Ca2+-ATPase of myocardial cells." @default.
- W2367773721 created "2016-06-24" @default.
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- W2367773721 date "2008-01-01" @default.
- W2367773721 modified "2023-09-28" @default.
- W2367773721 title "Preventive effect of Veratrum nigrum L.Var.ussurience Nakai alkaloids on cardiac hypertrophy induced by isoproterenol in mices" @default.
- W2367773721 hasPublicationYear "2008" @default.
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