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- W2367773794 abstract "Objective To study the drug resistance changes in Tca8113 cell lines by exposing to Carboplatin in the nude mice. Methods The Tca8113 cells were injected subcutaneously in both sides of armpit of nude mice. Two weeks after injection Carboplatin was used subcutaneously around the tumor. Mice were sacrificed about 13 weeks after drug inducing. The sensibility to drugs of the cells was analysed by MTT method. Immunocytochemistry and RT-PCR were utilized to examine the expression of MDR proteins and genes. Results After exposing to Carboplatin, the Tca8113/CBP-vo cells had higher drug-resistance to CBP, MTX, PYM, VCR and higher expression of MRP, GST-π than Tca8113 cells. Conclusion The study showed MDR phenotype was elevated obviously in the inducing group, and in vivo inducing MDR was a good way to establish investigation platform for MDR mechanisms and reversing study." @default.
- W2367773794 created "2016-06-24" @default.
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- W2367773794 date "2008-01-01" @default.
- W2367773794 modified "2023-09-23" @default.
- W2367773794 title "Multidrug Resistance of an in vivo Induced Carboplatin-Resistant Tca8113 Cell Line" @default.
- W2367773794 hasPublicationYear "2008" @default.
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