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- W2367802605 abstract "Objective To investigate percutaneous permeability and skin irritation of gastrodigenin so as to provide the basis on the development of transdermal drug delivery formulations.Methods The modified Franz diffusion cell method and the excised rat skin were used to evaluate the percutaneous permeability of gastrodigenin.The effects of various common-used solvents,transdermal enhancers,and particle carriers on the permeability of gastrodigenin were studied.The rabbit skin irritation test was used to evaluate the safety of gastrodigenin solutions and their gels.Results Gastrodigenin was easy to permeate rat abdominal skin.The penetration rate constant(Js) was 134.1 μg/(cm2.h),and transit dose accumulated in 24 h was 3 mg/cm2.The solubility and permeability of gastrodigenin could be enhanced by 30% EtOH,so it was an ideal solvent for gastrodigenin.Improvement effects of the transdermal enhancers(Azone,turpentine,and borneol) and the transdermal particle carriers(microemulsion and ethosomes) were not significant.The skin irritation test results indicated that neither gastrodigenin soultions nor their gels exerted irritative effects to the rabbit skin.Conclusion Gastrodigenin has good percutaneous permeability without skin irritation,so it is suitable for the transdermal drug delivery in the treatment of central nervous system diseases." @default.
- W2367802605 created "2016-06-24" @default.
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- W2367802605 date "2011-01-01" @default.
- W2367802605 modified "2023-09-23" @default.
- W2367802605 title "In vitro percutaneous permeability and skin irritation of gastrodigenin" @default.
- W2367802605 hasPublicationYear "2011" @default.
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