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- W2367831775 abstract "Objective To observe the changes in proportion of CD+4Foxp+3 regulatory T cells(Treg cells) in peripheral blood of acute stage and stable senile COPD patients,to analyze the correlation between Treg cells and pulmonary function of senile COPD patients.To investigate the role of Treg cells played at the onset of senile COPD.Methods 30 patients with acute stage senile COPD and 35 patients with stable senile COPD were investigated as group1 and group 2,they came from respiratory medicine of our hospital between February,2010 and December,2010.Another 25 healthy volunteers from epidemiology study were investigated as control group.All the participants filled out the unified questionnaire,recording about 99 variables including their general condition,smoking history etc and checking their pulmonary function.Every group′s blood samples was collected at 8 o′clock in the morning after 6 hours of fasting.The proportion of Treg cells in peripheral blood was measured by flow cytometry method.Results The proportions of group1,group2 and control group were((2.62±0.68)%),((0.86±0.46)%) and((1.45±0.70)%),there was significant difference between multiple pairwise comparisons(P0.05);The CD4 and CD25 double positive cell rate in peripheral blood of group1,group2 and control group were((3.90±1.64)%),((3.01±1.40)%) and((3.78±1.83)%),there was no difference among the 3 groups.The proportion of Treg cells in peripheral blood and FEV1% prep and FEV1/FVC% was not correlated(r=-0.158,-0.188 and P=0.136,0.076);there was not correlated between the proportion of Treg cells and age(r=0.014,P0.05).Conclusions Immune disorders may exist in COPD patients,and Treg cells may be involved in the process of the pathogenesis of senile COPD and acute exacerbation.There are no correlation between the proportion of Treg cells in peripheral blood and pulmonary function." @default.
- W2367831775 created "2016-06-24" @default.
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- W2367831775 date "2012-01-01" @default.
- W2367831775 modified "2023-09-26" @default.
- W2367831775 title "The change of CD_4~+ Foxp_3~+ regulatory T cells in different stages of senile COPD patients and their correlation with lung function" @default.
- W2367831775 hasPublicationYear "2012" @default.
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