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- W2367843700 abstract "Objective To investigate the effect of mesalazine treatment on the expression of NF-κB p65 in the spleen tissue of rats with 2,4,6-trinitrobenzenesulfonic acid( TNBS)-induced ulcerative colitis.Methods Forty-two SD rats were randomly divided into the control group,colitis model group and mesalazine group( 14 rats in each group).Apart from the control group,the rats in the other two groups were induced to ulcerative colitis by 2,4,6-trinitrobenzenesulfonic acid.And 2 days later,rats in the control and colitis model groups were administered intragastrically with distilled water at a dose of 3 mL,while rats in the mesalazine group was intragastrically given suspension of mixed mesalazine and distilled water at a dose of 3 mL.All rats were treated for 15 d.Spleen tissue samples were taken to detect the expression of mRNA of NF-κB p65 by RT-PCR and the protein by Western blot.Results The expression of the mRNA and protein of NF-κB p65 were significantly higher in the model group than those in the control group( all P 0.05).Treatment with mesalazine significantly decreased the expression of the mRNA and protein of NF-κB p65( all P 0.05).Conclusion Mesalazine plays an important role in the treatment of ulcerative colitis by down-regulating the expression of the mRNA and protein of NF-κB p65 in the spleen tissue of rats with TNBS-induced ulcerative colitis." @default.
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- W2367843700 date "2013-01-01" @default.
- W2367843700 modified "2023-09-25" @default.
- W2367843700 title "Effect of mesalazine on the expression of NF-κB p65 in the spleen tissue of rats with TNBS-induced ulcerative colitis" @default.
- W2367843700 hasPublicationYear "2013" @default.
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