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- W2367895953 abstract "Objective: To evaluate the effectiveness and safety of leuprolide acetate in the treatment of endometriosis.Methods: The patients with confirmed endometriosis were randomly divided into leuprolide(n=75) and control(n=74) groups.They were treated with either sustained-release injection of leuprolide acetate or Enatntone injection(control) for 3 times totally.After treatment,the ovarian mass volume was measured under B ultrasound;the changes in hormones(E2,FSH,LH),the pelvic signs,the scores of the patient's subjective symptoms during menstruation and non-menstrual days were observed.Results: The rates of changes in ovarian mass volume had no statistically significant difference between the two groups(P=0.495~0.965).The median of ovarian mass volume reduce rate was-62.14% in the test group,and it was-68.83% in the control group at 12 weeks after the treatments.The distinct improvement rates and improvement rates of total symptom scores during menstruation and non-menstrual days had no statistically significant difference between the two groups.Hormone(E2,FSH,LH) levels were reached the level of menopause,and returned to normal when menstruation resumed after treatment;there was no significant difference between the two groups.The difference in the incidence of adverse reactions between the two groups was not significant.Conclusion: Leuprolide acetate is effective and safe in the treatment of endometriosis." @default.
- W2367895953 created "2016-06-24" @default.
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- W2367895953 date "2009-01-01" @default.
- W2367895953 modified "2023-09-25" @default.
- W2367895953 title "Randomized,blind,parallel-controlled and multiple-centre clinical trial on the effectiveness and safety of leuprolide acetate in the treatment of endometriosis" @default.
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