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- W2367931523 abstract "Objective: To study the effects of Simo decoction on expression of secretin( Sec) and substance P( SP) in cold-constraint stressed mice,and to explore the mechanism of Simo decoction( SD) on functional gastrointestionl disorders( FGIDs). Method: Gastrointestinal dysfunction model was established by exerting the factors of cold-constraint stimulation. And then randomly treated with distilled water,Dicetel( 20. 3 mg·kg- 1) and SD at dosage of 1. 8,0. 9 g·kg- 1were given,for continuous 14 days. The content change of Sec and SP in serum was tested by ELISA. The expressions of Sec and SP in brain tissue were measured by immunohistochemical staining. Result: The expressions of Sec in brain and serum of model group were decreased, and SP in model group was increased,compared with the normal group( P 0. 01). The SD could increase the expression of Sec in brain tissue and serum, and reduce the expression of SP,which also had significant differences compared with the model group( P 0. 05 or P 0. 01). There was remarkable difference between SD high and low-dose group( P 0. 05). Conclusion: Simo decoction can regulate the expression of Sec and SP in cold-constraint stressed mice,which is one of possible mechanism." @default.
- W2367931523 created "2016-06-24" @default.
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- W2367931523 date "2014-01-01" @default.
- W2367931523 modified "2023-09-25" @default.
- W2367931523 title "Effects of Simo Decoction on Secretin and Substance P in Cold-constraint Stressed Mice" @default.
- W2367931523 hasPublicationYear "2014" @default.
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