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- W2367939562 abstract "OBJECTIVE The aim of this study was to evaluate and compare the prognostic values of ERCC1 and RRM1gene expression from tumor tissue and lymph node in predicting Disease-free Survival(DFS)in patients with completely resected NSCLC who received adjuvant vinorelbine plus cisplatin(NP)chemotherapy.METHODS The level of RRM1 and ERCC1protein expression in 106 NSCLC tumor tissue and 75 metastatic lymph nodes were determined by immunohistochemistry between August01,2008 and August 31,2012 at Shandong Cancer Hospital and Institute.The relationship between DFS and the expression of these two proteins was analyzed by follow up study.RESULTS RRM1 and ERCC1expression from tumor tissue and metastatic lymph nodes exhibited higher expression compared with adjacent tumor tissue and non-metastatic lymph nodes(P0.05).After received NP regimen chemotherapy,DFS was substantially improved in patients with RRM-negative tumors and lymph nodes when compared with patients with RRM1-positive tumors(23.1months versus 16.4months,P=0.007;24.7months versus 19.1months,P=0.026,respectively).In contrast,ERCC1 expression was not prognostic factors for DFS.CONCLUSIONS RRM1 but not ERCC1 expression showed prognostic value for DFS in patients with resected NSCLC with adjuvant NP regimen chemotherapy.Prospective studies that include a larger number of patients are needed for definite conclusions." @default.
- W2367939562 created "2016-06-24" @default.
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- W2367939562 date "2014-01-01" @default.
- W2367939562 modified "2023-09-23" @default.
- W2367939562 title "Evaluation of ERCC1 and RRM1 expression levels and prognostic impact for non-small cell lung cancer patients" @default.
- W2367939562 hasPublicationYear "2014" @default.
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