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- W2367939709 abstract "Objective] To study the relationship between environmental risk factors,genetic polymorphisms of metabolic enzymes and leukemia. [Methods] Matched case-control study was carried out to explore the relationship between environmental risk factors, genotypes of metabolic enzymes and the risk of leukemia. Conditional logistic regression model was applied to screen environmental risk factors. [Results] According to the preceding materials of epidemiology,the results showed that the decoration interval,the years of oxidant hair dye use were two of the environmental risk factors associated with leukemia. The findings of this study concerning the interaction among leukemia,hair dye use (OR:2.182,95%CI 1.224～3.828) or house decoration(OR:2.182,95%CI 1.224～3.828) and genetic polymorphism suggested that the incidence of leukemia increased as individuals carried the susceptible genotypes of CYP1A1(C/T,T/T) (P=0.0235) or GSTT1 (null type) (P=0.0042) while exposed to the hair dye or house decoration. [Conclusion] The interaction of risk factors mentioned above are stronger than the total actions of the two factors, thus playing a coordinated role in the development of leukemia." @default.
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- W2367939709 date "2004-01-01" @default.
- W2367939709 modified "2023-09-25" @default.
- W2367939709 title "Relationship between Environmental Risk Factors, Genetic Polymorphisms of Metabolic Enzymes and Leukemia" @default.
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