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- W2367939761 abstract "Objective:To synthesize linear polyethyleneimine grafted mPEG and PCL(mPEG-LPEI-PCL) as an amphiphilic cation polymer used to prepare cationic 10-hydroxycamptothecin nanoparticles(HCPT-NPs) and to evaluate its properties in vitro.Methods:IR and 1H-NMR were used to characterize the structure of the polymer,and HCPT-NPs were prepared by modified film dispersion method.Thereafter,the size,Zeta potential,entrapment efficiency,stability and morphology were studied.Additionally,the drug release performance of HCPT-NPs was tested using dialysis method in vitro.Results:The mean diameters,Zeta potential,entrapment efficiency and drug loading of HCPT-NPs were(155.6±9.6) nm,(29.6±3.2) mV,(92.6±1.1)% and(4.49±0.02)%,respectively.The drug release speed appeared faster with pH value increasing.Conclusion:The amphiphilic polymer mPEG-LPEI-PCL is successfully synthesized,which enables self-assembly to form cationic core-shell structure nanoparticles.The nanoparticles have good stability when stored at 4 ℃." @default.
- W2367939761 created "2016-06-24" @default.
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- W2367939761 date "2013-01-01" @default.
- W2367939761 modified "2023-09-23" @default.
- W2367939761 title "Preparation and property evaluation in vitro of 10-hydroxycamptothecin cationic polymer nanoparticles" @default.
- W2367939761 hasPublicationYear "2013" @default.
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