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- W2367963742 abstract "ObjectiveTo develop and validate an HPLC method for the simultaneous determination of Salvianolic acid B and Tanshinone IIA in plasma,brain tissue,cerebrospinal fluid and perilymph of guinea pig. MethodsChromatographic separation was performed on a C18 HPLC column,with gradient elution of 2% glacial acetic acid and methanol as mobile phase.The flow rate was 1 ml·min-1 and UV detector was set at 280nm. ResultsThe HPLC method showed good chromatographic resolution for Salvianolic acid B and Tanshinone IIA.The calibration curves were linear over the investigated concentration ranges with all correlation coefficients higher than 0.999.The extraction recoveries for the two components were between 74.76% and 104.27%,and the method recoveries were between 93.82% and 108.94%.The intra-and inter-day RSD were less than 7.87%. ConclusionThe proposed method is simple,selective and suitable for in vivo determination of Salvianolic acid B and Tanshinone IIA in guinea pig,which may provide the analytical method to their action mechanism and pharmacokinetics." @default.
- W2367963742 created "2016-06-24" @default.
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- W2367963742 date "2011-01-01" @default.
- W2367963742 modified "2023-09-28" @default.
- W2367963742 title "Determination of Salvianolic B and Tanshinone IIA in Guinea Pig by HPLC in vivo Simutaneously" @default.
- W2367963742 hasPublicationYear "2011" @default.
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