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- W2367976278 abstract "【Objective】 To investigate the effects of epigallocatechin gallate(EGCG)on the HepG2 cells proliferation in vitro and to explore the probably mechanism of the anti-tumor activity of EGCG.【Methods】 The cell growth of human hepatocellular carcinoma cell line HepG2 was quantified by MTT assay.The expressions of the regulatory proteins of cell cycle such as Cyclin D1 and anti-apoptosis protein such as Bcl-2 in hepatocellular carcinoma cell line.HepG2 was detected by immunocytochemical staining and Western blot method.【Results】 When hepatocellular carcinoma cell line HepG2 was treated with EGCG after 48 h,the medicine inhibited the cells proliferation in a dose-dependent fashion.With the increase of concentration,the OD decreased.Compared with control group,the inhibitory effect on cell proliferation increased.Immunohistochemical method and Western blot method showed that the expressions of Cyclin D1 and Bcl-2 were decreased after EGCG treatment.【Conclusion】 EGCG may inhabit the proliferation of hepatocellular carcinoma cells HepG2 obviously.The underlying molecular mechanism is that EGCG inhabits the cell proliferation through down-regulating the expressions of the regulation proteins of cell cycle such as Cyclin D1 and the expressions of anti-apoptosis protein such as Bcl-2 to cause cell cycle arrest and induce apoptosis.So this medicine is promising as a kind of new medicines in hepatocellular carcinoma chemotherapy." @default.
- W2367976278 created "2016-06-24" @default.
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- W2367976278 date "2012-01-01" @default.
- W2367976278 modified "2023-09-24" @default.
- W2367976278 title "Effects of catechin on cells proliferation and apoptosis in human hepatocellular carcinoma cell" @default.
- W2367976278 hasPublicationYear "2012" @default.
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