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- W2367982675 abstract "Objective To investigate the cellular immunity features of perioperative patients with gastric carcinoma and the effect of chemotherapy(5-fluorouraci,5-Fu)and immunotherapy(interferon alpha-1b,IFN-α1b)on T cell subsets,NK cell and MG7.Methods Fourty-nine patients underwent surgical resection were assigned at random into 3 groups.The patients(n=10)in group A were given operation without chemotherapy or IFN-α1b,in group B(n=18)chemotherapy with 5-Fu,0.5~0.75 mg i.v.drip,daily×3/week and in group C(n=21)immunotherapy with IFN-α1b,3 M.U.i.m,daily×3/week,in combination with 5-Fu.T cell subsets(CD4、CD8、CD4/CD8)and NK cell were determined before operation,and on the 14th,28th and 42nd postoperative day,and TMs were monitored operatively.Five-year follow-up results were obtained in some cases.Results CD4,CD4/CD8 and NK cells in patients with gastric carcinoma were lower than those in the normal.Treated with IFN-α1b for at least 6 weeks,the abrogation of 5-FU-induced suppression of cellular immunity could be found.Positive rate of MG7 was 69.38% and overall positive rate of TMs could be enhanced greatly.Median survival time was 44 months in IFN group and 30 months in CTL group,respectively.Conclusion 5-Fu in combination with IFN-α1b for at least 6 weeks can alleviate 5-Fu-induced suppression and this regimen shows its feasibility and safety.IFN-α1b does not change median survival time of patiens with gastric carcinoma.Monitoring of MG7 may be sed for the judgement of prognosis of gastric carcinoma." @default.
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- W2367982675 date "2007-01-01" @default.
- W2367982675 modified "2023-09-26" @default.
- W2367982675 title "The effect of 5-fluorouracil and interferon alpha-1b on T cell subsets,NK cell and MG_7 antigen in perioperative patients with gastric carcinoma" @default.
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