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- W2368023671 abstract "Objective To investigate the protective effect of nuclear factor E2-related factor 2(Nrf2) nuclear translocation on the high fat diet induced-insulin resistance in rats and to explore its possible mechanism.Methods Twenty-four male SD rats were randomized into 3 groups:control group(n=8),model group(n=8) and curcumine-treated group(n=8).Rats were given normal diet in control group,and high fat diet in the other groups.IR models were validated with hyperinsulinemic-euglycemic clamp test in model group and control group after 6 weeks.Then rats were continuously fed with normal diet in control group,high fat diet in model group,while the rats were additionally fed with oral curcumine at the dose of 200 mg/kg per day for 4 weeks based on high fat diet in curcumine-treated group.At the end of week 10,the levels of AST,ALT,malondialdehyde(MDA) and glutathione(GSH) were measured.The levels of Nrf2,JNK/p-JNK and IRS-1/p-IRS-1 were determined by Western blot,and the pathological changes of liver tissues were observed.Results Curcumine resulted in markedly nuclear translocation of Nrf2.Compared with control group,the levels of MDA,AST and ALT increased significantly in model group(P0.01).However,the levels of MDA,AST and ALT in curcumine-treated group decreased significantly compared with model group(P0.01).Compared with control group,the level of GSH decreased significantly in model group(P0.01).However,the levels of GSH in curcumine-treated group increased significantly compared with model group(P0.01).Compared with model group,the levels of p-IRS-1 increased and the level of p-JNK decreased in curcumine-treated group,but the levels of IRS-1 and JNK were not significantly different.Conclusion Nuclear translocation of Nrf2 can reduce oxidative stress injury and improve insulin resistance in rats." @default.
- W2368023671 created "2016-06-24" @default.
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- W2368023671 date "2011-01-01" @default.
- W2368023671 modified "2023-09-28" @default.
- W2368023671 title "Protective effect of Nrf2 on the high fat diet-induced insulin resistance in rats" @default.
- W2368023671 hasPublicationYear "2011" @default.
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