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- W2368026762 abstract "Objective:To investigate the estrogenic effect of the incompatibility of Veratrum nigrum and Panax gingseng on immature mouse.Method:One hundied and twenty female Kunming mice,were randomly divided into 12 groups:the normal group,estrogen receptor antagonist(ICI) group(5 mg·kg-1),the V.nigrum(VT) group,(0.045 g·kg-1),the low-,middle-and high-dose P.gingseng(GS) groups,(12,18,24 g·kg-1),ICI + low-dose GS group(ICI 5 mg·kg-1+ GS 12 g·kg-1),ICI + middle-dose GS group(ICI 5 mg·kg-1+GS 18 g·kg-1),ICI + high-doses GS group(ICI 5 mg·kg-1+ GS 24 g·kg-1),VT + low-dose GS group(VT0.045 g·kg-1+ GS 12 g·kg-1),VT + middle-dose GS group(VT 0.045 g·kg-1+ GS 18 g·kg-1),VT + highdose GS group(VT 0.045 g·kg-1+ GS 24 g·kg-1).The uterus index,estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),and the difference between uterine and vaginal histopathology were observed after 5 days.Result:Compared to the normal group,the uterus index increased(P 0.05),E2increased(P 0.05,P 0.01),levels of LH and FSH decreased(P 0.05) in all doses of GS groups.Meanwhile,the growth and development of the uterus and vagina were promoted.While GS used with VT,uterus index decreased(P 0.05,P 0.01),levels of E2 notably decreased(P 0.05,P 0.01),levels of LH and FSH increased(P 0.05,P 0.01),and the degree of uterus and vagina atrophy was increased.Conclusion:VT could impair the estrogenic effect of GS in a certain dosage." @default.
- W2368026762 created "2016-06-24" @default.
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- W2368026762 date "2015-01-01" @default.
- W2368026762 modified "2023-09-24" @default.
- W2368026762 title "Estrogenic Effect of Incompatibility of Veratrum nigrum and Panax gingseng on Immature Mouse" @default.
- W2368026762 hasPublicationYear "2015" @default.
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