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- W2368033367 abstract "AIM: To examine the effect of the sparfloxacin,alone and in combination with felbinac,on GABA-,NMDA-,AMPA-,and kainite-evoked currents. METHODS: GABA-,NMDA-,AMPA-,and kainite-evoked currents were recorded on dissociated hippocampal neurons of neonatal rat by whole-cell voltage-clamp technique. RESULTS: Spar- floxacin at 1 mmol·L -1 showed reversible rapid suppression on GABA (30 μmol·L -1 )-evoked currents with the rate of (47.6± s 2.9)%. Felbinac 10 μmol·L -1 alone exhibited no suppression but weakly enhanced the inhibitory effect when combined with sparfloxacin 1 mmol·L -1 . IC_ 50 values for sparfloxacin alone and in combination with felbinac on GABA response were (238±21) μmol·L -1 and (89± 5) μmol· L -1 ,respectively. Whole cell currents evoked by NMDA,AMPA or kainite were slightly influenced by sparfloxacin,felbinac,or sparfloxacin plus felbinac. CONCLUSION: These data suggest that the neurotoxicity of sparfloxacin alone or in combination with felbinac may be related to antagonism of GABA-evoked currents but not to an interaction at NMDA-,AMPA-,and kainite-evoked currents." @default.
- W2368033367 created "2016-06-24" @default.
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- W2368033367 date "2004-01-01" @default.
- W2368033367 modified "2023-09-25" @default.
- W2368033367 title "Effects of sparfloxacin and felbinac on GABA-A and ionotropic glutamate receptors in dissociated rat hippocampal neurons" @default.
- W2368033367 hasPublicationYear "2004" @default.
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