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- W2368036041 abstract "Objective To explore the anti-scarring effect of tetrandrine in rabbit models with glaucoma filtering surgery.Methods Twenty-one healthy rabbits were randomly divided into three groups: tetrandrin(TET) group,blank control group and mitomycin C(MMC) group.Glaucoma filtering surgery was conducted.0.2% TET and 0.002% MMC cotton sheets were respectively placed under the scleral flap for 5 minutes,and then were discarded.The eyes were rinsed with saline.The intraocular pressure,bleb,cornea and eyeground were checked on the 7th,30th and 60th day after the surgery.Tissues near the filter with a size of 4 mm × 2 mm were collected for electron microscopy and histopathological examination.Results As compared with the control group,intraocular pressure was decreased perpetually in TET group and most of the models could form a functional bleb without any complication.There was no connective tissue collagen in pathology.Electron microscope observation showed that the fibroblasts shrank and the cell gap was widened.The protein synthesis in the fibroblasts in the TET group were inhibited.Conclusions The anti-scarring effect of tetrandrine is superior to that of MMC in the anti-glaucoma filtration surgery.It can be widely applied as the ideal anti-metabolism and anti-proliferation drug." @default.
- W2368036041 created "2016-06-24" @default.
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- W2368036041 date "2013-01-01" @default.
- W2368036041 modified "2023-09-22" @default.
- W2368036041 title "Experimental Study on Anti-scarring Effect of Tetrandrine in Rabbit Models with Glaucoma Filtering Surgery" @default.
- W2368036041 hasPublicationYear "2013" @default.
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