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- W2368038161 abstract "Objective To evaluate the physicochemical property,dialysis reaction and biosecurity of amino-chitosan(AC)peritoneal dialysate and lay foundation for its further clinical application. Methods A new AC dialysate was constructed by referring to the formulation of icodextrin dialysate, and the PH, stability, colloidal property and antibacterial activity were measured. 126 SD rats were randomly divided into 7 groups and SD rats in each group were injected intraperitoneally with different concentrations of glucose dialysate, icodextrin dialysate and AC dialysate in 5 ml. The amounts of peritoneal fluid were measured at the 1,2,3,4,8 and 12. Pathological changes in liver, kidney, mesentery and peritoneum were closely detected during one-week intraperitoneal injection of AC dialyste. Results The new AC dialysate was colorless and transparent gel, with a Tyndall effect and p H 7.0 ~8.0. There was no insoluble precipitate after high temperature and pressure treatment, repeated freezing and thawing and other treatments. AC dialysate could inhibit the growth of both Escherichia coli and Staphylococcus aureus.1.0% and 1.5% of AC dialysate could increase intraperitoneal fluid and reached the maximum of(7.15 ±0.107)ml and(9.43 ±0.232)ml at 8 h, respectively. There were no statistically significant between 8 h and 12 h of intraperitoneal fluid(P 0.05). There were no significant pathological changes in liver, kidney and mesentery and no retroperitoneal fibrosis after 2 weeks injury in the AC group and glucose group.Conclusion Due to its high biosecurity, obvious dialysis reaction, slower dialysis rate and inhibitory effect on bacterial growth, the new AC dialysate has potential clinical application." @default.
- W2368038161 created "2016-06-24" @default.
- W2368038161 creator A5091737317 @default.
- W2368038161 date "2015-01-01" @default.
- W2368038161 modified "2023-09-26" @default.
- W2368038161 title "Dialysis safety study on a new kind peritoneal dialysate" @default.
- W2368038161 hasPublicationYear "2015" @default.
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