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- W2368049361 abstract "Objective:To evaluate effects on the antisense oligodeoxynucleotides inhibiting herpes simplex virus Ⅰ(HSV1) replication by the phosphorothioate modify and the liposome encapsulation.Methods:10 2TCID 50 (50% tissue culture infective dosage) virus and 20,10,5,2 5,1 25 μg/ml antisense oligodeoxynucleotides (AODN),antisense oligodeoxynucleotides liposome (AODNL),phosphorothioat antisense oligodeoxynucleotides (SAODN),phosphorothioat antisense oligodeoxynucleotides liposome (SAODNL) were added into 96 well cell culture plates.After the cells were cultured for 24 hours and frozen,the upper liquid was taken into 24 well cell culture plates.1 hour later,the virus was taken out and plaque liquid was added.The cells were culture for 72 hours and plaque was counted.The virus contrast was done and inhibitive rates were calculated.Results:The drug concentrations had no correlation to the effects.There were significant differences in AODN with AODNL,SAODN,and SAODNL.There were significant differences between SAODN and SAODNL,but no differences between AODNL and SAODNL.Conclusion:The inhibiting virus effects of phosphorothioate modify,liposome encapsulation and combination of both were stronger than those of free AODN.The inhibitive effects of liposome encapsulation were stronger than those of phosphorothioate modify." @default.
- W2368049361 created "2016-06-24" @default.
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- W2368049361 date "2002-01-01" @default.
- W2368049361 modified "2023-09-23" @default.
- W2368049361 title "Effects of phosphorothioat modify and liposome-encapsulation on the inhibition of HSV1 replication by the antisense oligodeoxynucleotides" @default.
- W2368049361 hasPublicationYear "2002" @default.
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