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- W2368063112 abstract "[Objective]To observe the effect of rosiglitazone on levels of blood glucose,blood lipid,high-sensitivity C-reactive protein(hs-CRP),tissue plasminogen activator(t-PA) and plasminogen activator inhibitor 1(PAI 1) in coronary heart diseases patient complicated with type 2diabetes mellitus. [Methods]50 patients were randomly divided into the treatment group(n=24) and the control group(n=26).The control group was treated with routine therapy,and the treatment group was given rosiglitazone 4mg/d on the basis of routine therapy.The levels of FPG,2hPG,HbA1c,TG,TC,LDL-C,HDL-C,hs-CRP,t-PA and PAI 1 of both groups were tested before treatment and after 12 weeks of treatment. [Results]After 12 weeks of treatment,the levels of FPG,2hPG and HbA1c of both groups decreased significantly as compared with those before treatment(P0.05 or P0.01),and all indexes of the treatment group were lower than those of control group(P0.05).The blood lipid indexes showed: the levels of TC and LDL-C of both groups decreased significantly after treatment as compared with those before treatment(P0.05),and the level of HDL-C increased significantly(P0.05).The anti-inflammatory indexes showed: the levels of hs-CRP of both groups decreased significantly as compared with those before treatment(P0.05 or P0.01),and all indexes of the treatment group were lower than those of control group(P0.05).The fibrinolytic system indexes showed: in the treatment group,the level of t-PA increased and the level of PAI 1decreased,and the differences were significant(P0.05). [Conclusion]On the basis of routine therapy,rosiglitazone can effectively control blood glucose level,regulate blood lipid level,play a role in anti-inflammatory and improve the pre-thrombotic state in coronary heart diseases patient complicated with type 2 diabetes mellitus." @default.
- W2368063112 created "2016-06-24" @default.
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- W2368063112 date "2011-01-01" @default.
- W2368063112 modified "2023-09-25" @default.
- W2368063112 title "Clinical Observation of Rosiglitazone on Coronary Heart Diseases Patients Complicated with Diabetes Mellitus" @default.
- W2368063112 hasPublicationYear "2011" @default.
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