Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368073896> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2368073896 endingPage "8" @default.
- W2368073896 startingPage "306" @default.
- W2368073896 abstract "To study the effects of retinoic acid on regulation of expressions of cyclin-dependent kinase inhibitors, i.e. p16, p21 and p27 in cultured rat hepatic stellate cells.Stellate cells were isolated from healthy rat livers and cultured. After stimulated with 1 ng/ml transforming growth factor beta 1, subcultured hepatic stellate cells were treated with or without 1 nmol/ml retinoic acid. MTT assay, immunocytochemistry for p16, p21, p27 and alpha-smooth muscle actin protein, in situ hybridization for retinoic acid receptor beta 2 and p16, p21 and p27 mRNA and quantitative image analysis (partially) were performed.Retinoic acid markedly inhibited hepatic stellate cells proliferation (41.50%, P<0.05), decreased the protein level of alpha-smooth muscle actin (55.09%, P<0.05), and induced hepatic stellate cells to express retinoic acid receptor beta 2 mRNA. In addition, retinoic acid increased the protein level of p16 (218.75%, P <0.05) and induced p21 protein expression; meanwhile, p27 was undetectable by immunocytochemistry in both control and retinoic acid-treated hepatic stellate cells. However, retinoic acid had no influence on the mRNA level of p16, p21 or p27 as determined by in situ hybridization.Up-regulation of p16 and p21 on post-transcriptional level may contribute, in part, to retinoic acid inhibition of transforming growth factor beta 1-initiated rat hepatic stellate cells activation in vitro." @default.
- W2368073896 created "2016-06-24" @default.
- W2368073896 creator A5000009881 @default.
- W2368073896 creator A5030103223 @default.
- W2368073896 creator A5040225098 @default.
- W2368073896 date "2001-10-01" @default.
- W2368073896 modified "2023-09-23" @default.
- W2368073896 title "[Evidence for retinoic acid modulating expression of cyclin-dependent kinase inhibitors in rat hepatic stellate cells]." @default.
- W2368073896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11676881" @default.
- W2368073896 hasPublicationYear "2001" @default.
- W2368073896 type Work @default.
- W2368073896 sameAs 2368073896 @default.
- W2368073896 citedByCount "0" @default.
- W2368073896 crossrefType "journal-article" @default.
- W2368073896 hasAuthorship W2368073896A5000009881 @default.
- W2368073896 hasAuthorship W2368073896A5030103223 @default.
- W2368073896 hasAuthorship W2368073896A5040225098 @default.
- W2368073896 hasConcept C104317684 @default.
- W2368073896 hasConcept C105580179 @default.
- W2368073896 hasConcept C119775778 @default.
- W2368073896 hasConcept C120197328 @default.
- W2368073896 hasConcept C126322002 @default.
- W2368073896 hasConcept C134018914 @default.
- W2368073896 hasConcept C139522298 @default.
- W2368073896 hasConcept C1491633281 @default.
- W2368073896 hasConcept C153911025 @default.
- W2368073896 hasConcept C176891718 @default.
- W2368073896 hasConcept C185592680 @default.
- W2368073896 hasConcept C19431177 @default.
- W2368073896 hasConcept C199835354 @default.
- W2368073896 hasConcept C2779963572 @default.
- W2368073896 hasConcept C2781121885 @default.
- W2368073896 hasConcept C29537977 @default.
- W2368073896 hasConcept C35866371 @default.
- W2368073896 hasConcept C54355233 @default.
- W2368073896 hasConcept C55493867 @default.
- W2368073896 hasConcept C71924100 @default.
- W2368073896 hasConcept C81439078 @default.
- W2368073896 hasConcept C81885089 @default.
- W2368073896 hasConcept C86803240 @default.
- W2368073896 hasConcept C89364313 @default.
- W2368073896 hasConcept C95444343 @default.
- W2368073896 hasConceptScore W2368073896C104317684 @default.
- W2368073896 hasConceptScore W2368073896C105580179 @default.
- W2368073896 hasConceptScore W2368073896C119775778 @default.
- W2368073896 hasConceptScore W2368073896C120197328 @default.
- W2368073896 hasConceptScore W2368073896C126322002 @default.
- W2368073896 hasConceptScore W2368073896C134018914 @default.
- W2368073896 hasConceptScore W2368073896C139522298 @default.
- W2368073896 hasConceptScore W2368073896C1491633281 @default.
- W2368073896 hasConceptScore W2368073896C153911025 @default.
- W2368073896 hasConceptScore W2368073896C176891718 @default.
- W2368073896 hasConceptScore W2368073896C185592680 @default.
- W2368073896 hasConceptScore W2368073896C19431177 @default.
- W2368073896 hasConceptScore W2368073896C199835354 @default.
- W2368073896 hasConceptScore W2368073896C2779963572 @default.
- W2368073896 hasConceptScore W2368073896C2781121885 @default.
- W2368073896 hasConceptScore W2368073896C29537977 @default.
- W2368073896 hasConceptScore W2368073896C35866371 @default.
- W2368073896 hasConceptScore W2368073896C54355233 @default.
- W2368073896 hasConceptScore W2368073896C55493867 @default.
- W2368073896 hasConceptScore W2368073896C71924100 @default.
- W2368073896 hasConceptScore W2368073896C81439078 @default.
- W2368073896 hasConceptScore W2368073896C81885089 @default.
- W2368073896 hasConceptScore W2368073896C86803240 @default.
- W2368073896 hasConceptScore W2368073896C89364313 @default.
- W2368073896 hasConceptScore W2368073896C95444343 @default.
- W2368073896 hasIssue "5" @default.
- W2368073896 hasLocation W23680738961 @default.
- W2368073896 hasOpenAccess W2368073896 @default.
- W2368073896 hasPrimaryLocation W23680738961 @default.
- W2368073896 hasRelatedWork W1554640292 @default.
- W2368073896 hasRelatedWork W1965719081 @default.
- W2368073896 hasRelatedWork W2053761218 @default.
- W2368073896 hasRelatedWork W2068417079 @default.
- W2368073896 hasRelatedWork W2075220388 @default.
- W2368073896 hasRelatedWork W2092245381 @default.
- W2368073896 hasRelatedWork W2099334382 @default.
- W2368073896 hasRelatedWork W2326252610 @default.
- W2368073896 hasRelatedWork W2368073896 @default.
- W2368073896 hasRelatedWork W3089047030 @default.
- W2368073896 hasVolume "9" @default.
- W2368073896 isParatext "false" @default.
- W2368073896 isRetracted "false" @default.
- W2368073896 magId "2368073896" @default.
- W2368073896 workType "article" @default.