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- W2368082197 abstract "Objective To explore the potential association between the heparan sulfate proteoglycan gene (HSPG) polymorphism and genetic susceptibility to calcium oxalate nephrolithiasis in the Chinese Han population. Methods 143 patients diagnosed with calcium oxalate urolithiasis were enrolled in this study. In addition,157 age-matched healthy controls were enrolled. Genomic DNA was extracted from blood samples. Based on a case-control study,HSPG polymorphism (rs3767140) was determined by polymerase chain reaction and restriction fraction length polymorphism(PCR-RFLP) with BamHⅠ digestion. Results Distribution frequencies of site rs3767140 genotype and alleles in the two groups followed the Hardy-Weinberg equilibrium. Distribution frequencies of the GG+GT and TT genotypes were 69.23% and 30.77% in the oxalate calcium urolithiasis group and 79.62% and 20.38% in the healthy control group. Differences between the two groups were statistically significant(P0.05). Distribution frequencies of the G and T alleles in the two groups were respectively 45.10% and 55.90% and 54.14% and 45.86% with statistical differences (P0.05). Subjects with the TT genotype yielded a 1.736-fold increased risk for calcium oxalate nephrolithiasis,compared with subjects with the GT+GG genotype(OR=1.736,95% CI=1.026～2.938),however,we did not find an association between HSPG gene polymorphism and the possibility of stone recurrence. Conclusion There is a significant association between HSPG gene polymorphism and calcium oxalate nephrolithisis,and the TT genotype may be a good genetic marker." @default.
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- W2368082197 date "2010-01-01" @default.
- W2368082197 modified "2023-09-23" @default.
- W2368082197 title "Heparan sulfate proteoglycan gene polymorphism and genetic susceptibility to calcium oxalate nephrolithiasis" @default.
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