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- W2368085127 abstract "Objective: To study the effects of recombinant human platelet-derived growth factor-BB( rhPDGF-BB) combined with recombinant human transforming growth factor-β1( rhTGF-β1) on the expression of FAK mRNA of osteoclasts in the alveolar bone on the pressure side of orthodontic teeth in rats. Methods: Orthodontic tooth movement model was established in 160 male SD rats. The rats in experimental group were treated by injection of 10 ng rhPDGF-BB and 5 ng rhTGF-β1in the buccal submucosal area of the molar every other day from day 1 afterburner,while those in control group received equivalent volumes of PBS. The rats were sacrificed at 1,4,7,10 and 14 days( n = 16) after appliance placement. Specimens were collected. Osteoclasts in the alveolar bone on the pressure side of the orthodontic teeth were observed by TRAP staining,the FAK mRNA expression was quantified by quantitative RTPCR. Results: rhPDGF-BB combined with rhTGF-β1significantly promoted an increasing number of osteoclasts on the compressing side( P 0. 05),increased the expression of FAK mRNA at day 4 and 7( P 0. 05),then decresed it to the control level( P 0. 05)at day 14. Conclusion: Combination of rhPDGF-BB and rhTGF-β1can increase the number of osteoclasts in the alveolar bone on compressing side,and promote FAK mRNA expression in osteoclasts." @default.
- W2368085127 created "2016-06-24" @default.
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- W2368085127 date "2014-01-01" @default.
- W2368085127 modified "2023-09-26" @default.
- W2368085127 title "The effects of rhPDGF-BB combined with rhTGF-β_1 on FAK mRNA expression of osteoclasts in the alveolar bone on the pressure side of orthodontic teeth in rats" @default.
- W2368085127 hasPublicationYear "2014" @default.
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