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- W2368085237 abstract "Objective To observe the influence of peroxynitrite (ONOO-) on vasoconstrictive function of thoracic aorta in diabetic rats. Methods Male SD rats (n=30) were randomly divided into control group,diabetes group and diabetes+urate incubation (peroxynitrite scavenger) group (urate group). Taking rat thoracic aorta after removing endothelium cells as test sample,the differences in vasoconstrictive function,and expressions of RhoA/ROCK and nitrotyrosine were detected in all groups. Results The vasoconstrictive response was increased in diabetes group. The expression of RhoA mRNA was higher in diabetes group than that in urate group. The expressions of ROCK protein and nitrotyrosine increased significantly in diabetes group. Conclusion Peroxynitrite can increase the expression of ROCK protein and promote vasoconstrictive response in rats with diabetes induced by peroxynitrite." @default.
- W2368085237 created "2016-06-24" @default.
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- W2368085237 date "2012-01-01" @default.
- W2368085237 modified "2023-09-23" @default.
- W2368085237 title "Influence of peroxynitrite on vasoconstrictive function in diabetic rats" @default.
- W2368085237 hasPublicationYear "2012" @default.
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