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• W2368093880 abstract "Abstract This study aimed to assess the effect of the M20 interleukin-1 (IL-1) inhibitor on normal and leukemic hematopoietic cells. The M20-derived IL-1 inhibitor was found to inhibit the growth of various hematopoietic cells. The in vitro proliferation of myeloid cell lines in serum- containing medium or proliferation of these cells induced by IL-1 in serum-free medium (measured by 3H-TdR) were inhibited by the M20 IL-1 inhibitor. In addition, growth of normal progenitors and fresh leukemic cells stimulated by granulocyte-macrophage colony-stimulating factor (GM-CSF) (as measured by colony and liquid systems) was also inhibited by this factor. After the removal of the IL-1 inhibitor at the peak of growth inhibition, leukemic and normal progenitor cells retain their ability to grow and develop into GM-CSF colonies. These results show that the growth inhibition phenomena were reversible and did not result from a cytotoxic effect. Our data suggest that the M20-derived IL-1 inhibitor might function as a true negative growth regulator of normal and leukemic hematopoietic cells." @default.
• W2368093880 created "2016-06-24" @default.
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• W2368093880 date "1992-03-01" @default.
• W2368093880 modified "2023-09-28" @default.
• W2368093880 title "Effect of M20 interleukin-1 inhibitor on normal and leukemic human myeloid progenitors" @default.
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• W2368093880 doi "https://doi.org/10.1182/blood.v79.5.1172.1172" @default.
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• W2368093880 hasPublicationYear "1992" @default.
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