Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368098052> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2368098052 abstract "Objective To determine the effects of ketamine and its 50% effective dose(ED50) during its therapeutic use against strychnine-induced convulsions in mice.Methods Kunming mice randomly divided into six groups(n=10) were given intraperitoneal injection of saline 0.1 ml/10 g or doses of ketamine(24.5,35.0,50.0,71.4 and 102.0 mg/kg),respectively.5 minutes later,0.1 ml/kg of 1.5 mg/kg strychnine nitrate was administered i.p.to observe the incidence of seizures in mice,latency,duration of tonic state and mortality,and to determine the anticonvulsant ED50 of ketamine against strychnine-induced convulsions in mice using sequential method and spot-slope method.Results Compared with the NS group,the incidences of seizures decreased in K50.0,K71.4 and K102.0 groups(P0.05,P0.01);the mortalities significantly decreased in K35.0,K50.0,K71.4 and K102.0 groups(P0.05,P0.01),the seizure latencies were prolonged in all groups(P0.05,P0.01);in a dose-dependent manner each group can be shortened seizure latency(P0.05,P0.01),and a dose-dependent manner(r=0.9740,P0.01).The 95% authentic range of ketamine ED50 against strychnine convulsion was 44.8-64.3 mg/kg by the grouping method and 39.3-74.8 mg/kg by the sequential method.Conclusion The anticonvulsant mechanisms of ketamine may be associated with glycin receptor." @default.
- W2368098052 created "2016-06-24" @default.
- W2368098052 creator A5062277357 @default.
- W2368098052 date "2009-01-01" @default.
- W2368098052 modified "2023-09-28" @default.
- W2368098052 title "Effects of ketamine against strychnine-induced convulsions and the determination of its ED_(50) in mice" @default.
- W2368098052 hasPublicationYear "2009" @default.
- W2368098052 type Work @default.
- W2368098052 sameAs 2368098052 @default.
- W2368098052 citedByCount "0" @default.
- W2368098052 crossrefType "journal-article" @default.
- W2368098052 hasAuthorship W2368098052A5062277357 @default.
- W2368098052 hasConcept C118552586 @default.
- W2368098052 hasConcept C126322002 @default.
- W2368098052 hasConcept C170493617 @default.
- W2368098052 hasConcept C2775858608 @default.
- W2368098052 hasConcept C2777010014 @default.
- W2368098052 hasConcept C2777397205 @default.
- W2368098052 hasConcept C2777725853 @default.
- W2368098052 hasConcept C2778186239 @default.
- W2368098052 hasConcept C2780159080 @default.
- W2368098052 hasConcept C2780795376 @default.
- W2368098052 hasConcept C42219234 @default.
- W2368098052 hasConcept C42533223 @default.
- W2368098052 hasConcept C71924100 @default.
- W2368098052 hasConcept C98274493 @default.
- W2368098052 hasConceptScore W2368098052C118552586 @default.
- W2368098052 hasConceptScore W2368098052C126322002 @default.
- W2368098052 hasConceptScore W2368098052C170493617 @default.
- W2368098052 hasConceptScore W2368098052C2775858608 @default.
- W2368098052 hasConceptScore W2368098052C2777010014 @default.
- W2368098052 hasConceptScore W2368098052C2777397205 @default.
- W2368098052 hasConceptScore W2368098052C2777725853 @default.
- W2368098052 hasConceptScore W2368098052C2778186239 @default.
- W2368098052 hasConceptScore W2368098052C2780159080 @default.
- W2368098052 hasConceptScore W2368098052C2780795376 @default.
- W2368098052 hasConceptScore W2368098052C42219234 @default.
- W2368098052 hasConceptScore W2368098052C42533223 @default.
- W2368098052 hasConceptScore W2368098052C71924100 @default.
- W2368098052 hasConceptScore W2368098052C98274493 @default.
- W2368098052 hasLocation W23680980521 @default.
- W2368098052 hasOpenAccess W2368098052 @default.
- W2368098052 hasPrimaryLocation W23680980521 @default.
- W2368098052 hasRelatedWork W163640509 @default.
- W2368098052 hasRelatedWork W1967841507 @default.
- W2368098052 hasRelatedWork W1975688895 @default.
- W2368098052 hasRelatedWork W1981320574 @default.
- W2368098052 hasRelatedWork W1991015983 @default.
- W2368098052 hasRelatedWork W2016245284 @default.
- W2368098052 hasRelatedWork W2020267821 @default.
- W2368098052 hasRelatedWork W2036503945 @default.
- W2368098052 hasRelatedWork W2039877200 @default.
- W2368098052 hasRelatedWork W2088101006 @default.
- W2368098052 hasRelatedWork W2383231875 @default.
- W2368098052 hasRelatedWork W2405256892 @default.
- W2368098052 hasRelatedWork W2411376564 @default.
- W2368098052 hasRelatedWork W2422801106 @default.
- W2368098052 hasRelatedWork W2588507627 @default.
- W2368098052 hasRelatedWork W2704306316 @default.
- W2368098052 hasRelatedWork W3020381821 @default.
- W2368098052 hasRelatedWork W2109573377 @default.
- W2368098052 hasRelatedWork W2560776316 @default.
- W2368098052 hasRelatedWork W3084097080 @default.
- W2368098052 isParatext "false" @default.
- W2368098052 isRetracted "false" @default.
- W2368098052 magId "2368098052" @default.
- W2368098052 workType "article" @default.