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- W2368110074 abstract "Objective:To study the influence of modified Guizhi Fuling Granules on microvessel density(MVD) counting and expression of bcl-2 gene in prostate tissue of rats with benign prostatic hyperplasia,and clarify the molecular biological mechanism of modified Guizhi Fuling Granules in intervening angiogenesis and growth of stromal cells in prostate.Methods:80 rats were randomly divided into blank control group,blank hyperplasia group,modified Guizhi Fuling Granule group and finasteride group.After model establishing,rats in each group received corresponding treatments.The growth situation of prostate tissue of rats in each group was observed,the expression of MVD in prostate tissue was detected by using immunohistochemical technique,and the expression of Bcl-2 gene in prostate tissue was detected by using FCM.Results:The difference in the two indicators among modified Guizhi Fuling Granule group,finasteride group and blank control group was significant(P0.01),while there was no significant difference between modified Guizhi Fuling Granule group and finasteride group.Conclusion:Modified Guizhi Fuling Granule could significantly decrease MVD counting,expression of bcl-2 gene and angiogenesis,accelerate the apoptosis of gland cells,and reduce the producing of stromal cells in prostate tissue of rat,which may be an important mechanism for modified Guizhi Fulinq Granule in treating benign prostatic hyperplasia." @default.
- W2368110074 created "2016-06-24" @default.
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- W2368110074 date "2016-01-01" @default.
- W2368110074 modified "2023-09-23" @default.
- W2368110074 title "Influence of modified Guizhi Fuling Granules on MVD counting and expression of bcl-2 gene in rats with benign prostatic hyperplasia" @default.
- W2368110074 hasPublicationYear "2016" @default.
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