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- W2368115928 abstract "Objective Using self made bag in box system to observe the feasibility, sensitivity, reproducibility, and safety of on line measurement of the rabbit′s functional residual capacity (FRC) during conventional mechanical ventilation (CMV). Method The bag in box system is designed by using closed circuit rebreathing helium dilution technique to measure FRC during CMV. Ten healthy rabbits were randomly allocated into two groups: health and acute lung injury (ALI) group, 5 rabbits for each. After anesthetized and per oral endotracheal intubation with ligation around the tracheal tube, CMV started. ALI was induced by infusing oleic acid intravenously. Sixty ml of gases (0 1 of He, 0 3 of O 2 and 0 6 of N 2) was filled into the bag each time. (1) Different rebreathing times were applied for the rabbits to rebreath gases from the bag. By measuring helium concentration in the bag, the rebreathing times needed for helium equilibration were determined. (2) By using the same method to measure FRC, the positive end expiratory pressure ( PEEP ) was changed. PEEP was elevated by 2 and 4 cmH 2O, and then decreased by 2 and 4 cmH 2O in healthy group; and elevated 2 cmH 2O then decreased 2 cmH 2O in ALI group. The measurement was made in triplicate, at each PEEP level. During the experiment, invasive blood pressure and heart rate were monitored. The oxygen concentration in rebreathing bag and arterial blood gases were analyzed. Results It showed that helium reached equilibration between rebreathing bag and rabbit′s lung after rebreathing 25 30 times (about 37 45 s) in health group, and 20 25 times (about 30 37 s) in ALI group. The coefficient of variation did not exceed 0 07 in each PEEP level. The FRC correlated positively with PEEP in two groups ( r=0 78, P 0 05). The rebreathing process did not influence the rabbit′s blood pressure, heart rate and arterial blood gases except that PaCO 2 increased 15 mmHg in CMV health group ( P 0 05).Conclusion It is available using self made bag in box system to measure FRC without interrupting CMV in healthy and ALI rabbits induced by oleic acid. The system showed good reproducibility, sensitivity and safety." @default.
- W2368115928 created "2016-06-24" @default.
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- W2368115928 date "2001-01-01" @default.
- W2368115928 modified "2023-09-26" @default.
- W2368115928 title "On-line measurement of animal′s lung volume during conventional mechanical ventilation" @default.
- W2368115928 hasPublicationYear "2001" @default.
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