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- W2368119601 abstract "Objective To explore the relationship between intrahepatic immune competent cells and the status of chronic HBV infection in patients with HBV recurrence after orthotopic liver transplantation(OLT).Methods 12 liver biopsies,collected from HBV recurrent patients after OLT were detected by immunohistochemistry for the expression of intrahepatic CD3+,CD4+,CD8+,CD4+CD25+ regulatory T cell(Treg) T lymphocytes,and compared with 12 chronic hepatitis B(CHB) liver biopsies.Results Lymphocyte infiltrated mainly concentrated in the portal area.The number of CD3+,CD4+,CD8+ T cells were reduced and the number of Treg were increased significantly in HBV recurrent patients after OLT compared with CHB(P0.05).The expression of Treg were associated with pathology grade.The high expression of Treg was associated with the high viral load and the positive immunohistochemical expression of HBsAg,HBeAg were enhanced.Conclusion Immunosuppression exists in HBV recurrent patients after OLT and pathological damage was lighter than CHB.Intrahepatic Treg may play important roles in immune suppression,and control of liver inflammation and viral replication." @default.
- W2368119601 created "2016-06-24" @default.
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- W2368119601 date "2012-01-01" @default.
- W2368119601 modified "2023-09-24" @default.
- W2368119601 title "Expression and research of intrahepatic CD3~+,CD4~+,CD8~+,CD4~+CD25~+ regulatory T cell(Treg) in patients with HBV recurrence after liver transplantation" @default.
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