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- W2368125625 abstract "Aim: To study the chronopharmacokinetics of nifedipine at different administration times in rabbits. Methods: Nifedipine was administrated to rabbits by a single dose at different times.The HPLC was used to determine the plasma concentration of nifedipine.Results:AUC,t_ max ,and C_ max after nifedipine administration at 8 GA6FA 00 were 974.69 μg/(L·h), 0.91 h ,162.15 μg/L, respectively. AUC,t_ max ,and C_ max after nifedipine administration at 20 GA6FA 00 were 536.29 μg/( L· h),1.35 h,93.61 μg/L,respectively. Statistical significant difference was observed in these pharmacokinetic parameters at different administration times(P0.01). The pharmacokinetics of nifedipine in rabbits accorded with the one compartment model with the 1st order absorption after the administration,showing obvious dose-time dependent changes. Conclusion: Administration in morning can improve the bioavailability of nifedipine." @default.
- W2368125625 created "2016-06-24" @default.
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- W2368125625 date "2005-01-01" @default.
- W2368125625 modified "2023-09-23" @default.
- W2368125625 title "Chronopharmacokinetics of nifedipine in rabbits" @default.
- W2368125625 hasPublicationYear "2005" @default.
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