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- W2368131134 abstract "Objective:To investigate the expression of transforming growth factor-β1(TGF-β1) in the splenic tissues from patients with hypersplenism induced by portal hypertension(PH),idiopathic thrombocytopenic purpura(ITP) and hemolytic anemia(HA) respectively and its role in splenic fibrosis. Methods:According to the etiopathogenisis,the splenectomy specimens were divided into group A(PH or cirrhosis induced hypersplenism),group B(ITP induced hypersplenism),group C(HA induced hypersplenism) and group D(traumatic rupture of the spleen as the control),with 20 cases in each group.The morphological features of the specimens were observed through HE and Mason staining,and their TGF-β1 expressions were detected by Western blot analysis. Results:The HE and Mason staining showed that the splenic tissues of group A,B and C all presented different degrees of fibrosis,and that in group A had the most severe fibrosis,but no fibrotic change was noted in the specimens of group D.Western blot showed that the TGF-β1 expressions of the group A,B and C were all significantly higher than that of the group D(all P0.05),but these had no statistical differences among the group A,B and C(P0.05). Conclusion:There is overexpression of TGF-β1 in splenic tissue of the patients with hypersplenism,and it may be one of the mechanisms for the severe splenic fibrosis in these patients." @default.
- W2368131134 created "2016-06-24" @default.
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- W2368131134 date "2012-01-01" @default.
- W2368131134 modified "2023-09-26" @default.
- W2368131134 title "Expression of transforming growth factor-β1 in splenic tissues of patients with hypersplenism of different etiopathogenisis and its significance" @default.
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