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- W2368133639 abstract "Objective:To explore the β-endorphin(β-EP),dynorphinA_(1-13)(DynA_(1-13))and leu—enkephalin(L—ENK) levels in the plasma and cerebrospinal fluid(CSF)of patients with cerebral hemorrhage,and the effect of naloxone on them.Methods:The sixty patients with cerebral hemorrhage were randomly divided into 2 groups:control group(n=30)and naloxone—treated group(n=30).The control group received 14-day routine treatment and the naloxone—treated group received 14-day naloxone treatment intravenousl(3.0 mg/d)besides routine treament.We measured the concentrations of β-EP,DynA_(1-13) and L—ENK of 60 patients with cerebral hemorrhage during the acute stage before treatment and at 14 day after treatment by RIA and compared with those of normal group(the patients were treated by operations).The scores of NDS before and after treatment were examined at the same time.Results:(1) The levels of β-EP and DynA_(1-13) in the plasma and CSF of patients with cerebral hemorrhage were obviously higher after its onset than those of the normal group(P0.01);(2) There were significant differences between the levels of β-EP,DynA_(1-13) and L—ENK in the plasma and CSF of patients with cerebral hemorrhage after the treatment(P0.05 or P0.01).(3) The scores of NDS of naloxone—treated group showed a significant difference compared with those of control group after the treatment(P0.05).Conclusion:(1) The content of opioid peptide in the plasma and CSF obviously increased immediately after intracerebral hemorrhage;(2) Naloxone can resist the abnormal elevation of opioid peptide,with the function of protecting the brain." @default.
- W2368133639 created "2016-06-24" @default.
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- W2368133639 date "2005-01-01" @default.
- W2368133639 modified "2023-09-23" @default.
- W2368133639 title "Opioid peptide content in the plasma and cerebrospinal fluid of patients with cerebral hemorrhage and effect of naloxone on it" @default.
- W2368133639 hasPublicationYear "2005" @default.
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