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- W2368135462 abstract "Objectives To explore the effect of different factors on the concentration of neuropeptide Y(NPY)in plasma during pericardiopulmonary bypass of children’s heart surgery and their clinical significance. Methods Twenty children with congenital heart diseases were chosen to take blood samples from central vein to determine plasma NPY concentration by radioimmunoassay method before cardiopulmonary bypass(CPB),7 min. after CPB,at termination of CPB,and 12 hours post-operation. Effects of different factors,including age,types of congenital heart di-seases,pulmonary hypertension and the duration of CPB,on the changes of NPY in plasma were analyzed. Results (1)Significant increase of NPY were found 7 min. after CPB and at termination of CPB(P 0.05);it restored the pre-cardiopulmonary bypass baselines at 12 hours post-operation.(2)There were no differences in NPY concentration between patients younger or older than 7 years old(P 0.05).(3)There were significant differences of NPY concentration 7 min. after CPB and at termination of CPB between mild group(VSD,ASD)and complex group(TOF,others)(P 0.05).(4)Pulmonary hypertension showed no significant effect on the concentration of NPY(P 0.05). (5)Duration of CPB had positive correlation with the concentration of NPY(r = 0.459,P 0.05). Conclusions Cardiopulmonary bypass is a non-physiological perfusion,it can cause significant increase of NPY in plasma. Types of congenital heart diseases and duration of CPB have significant influence on NPY,while patient’s age and the pulmonary hypertension have little effect on NPY." @default.
- W2368135462 created "2016-06-24" @default.
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- W2368135462 date "2007-01-01" @default.
- W2368135462 modified "2023-09-23" @default.
- W2368135462 title "Influences and significance of different factors on plasma neuropeptide Y during pericardiopulmonary bypass of children’s heart surgery" @default.
- W2368135462 hasPublicationYear "2007" @default.
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