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- W2368137002 abstract "AIM:To develop an analytical method for quantitation of plasma 5-(4-phenoxybutoxy) psoralen(PAP-1) concentrations after dermal administration in rats by using high-performance liquid chromatography with ultraviolet(HPLC-UV). METHODS:Plasma was extracted by ethyl acetate using isoimperatorin as an internal standard and separated by HPLC on a C18 reversed-phase column using the mobile phase of methanol-water(75:25,V/V) at a flow rate of 0.8 mL/min.PAP-1 was quantitated using the ratio of the area of the analyte to the area of the internal standard.Plasma concentrations of PAP-1 were determined after dermal administration.RESULTS:The limited of detection was 5.3 μg/L(S/N10).Calibration curves were linear over the range of 5.3 to 2120 μg/L.The intra and inter-assay variability ranged from 2.3% to 6.0%,and the accuracy ranged from 102%-105%,for the low,medium and high quality control samples.The extraction recovery of PAP-1 from plasma was in the range of 83.1% to 86.5%.Following a single dermal dose of 15 mg/kg,the plasma PAP-1 level reached the peak at 4 h.AUC values were 256 and 1209 μg·L-1·h while Cmax values were 74 and 225 μg/L for male and female rats,respectively.CONCLUSION:The method is rapid,specific and sensitive,and can be used to determine plasma concentrations of PAP-1 for pharmacokinetic experiments.PAP-1 exhibits a significant gender differences after dermal administration in rats." @default.
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- W2368137002 date "2010-01-01" @default.
- W2368137002 modified "2023-09-23" @default.
- W2368137002 title "Determination of plasma 5-(4-phenoxybutoxy) psoralen concentrations by HPLC-UV after dermal administration in rats" @default.
- W2368137002 hasPublicationYear "2010" @default.
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