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- W2368144620 abstract "Objective To observe the protective effect of Buyanhuanwu decoction (BHD) after intracerebral hemorrhage(ICH) in rats. Methods The ICH model was made with injecting Ⅶtype collagenase stereotaxically into the globas pallidus of rats. The expression of activated Caspase-3 was examined with Immunohistochemical methods, and the degree of the hematoma was measured at different time. Results The peak value of positive cells around the hematoma was the most at 1st day, then descended at 2nd days and descended distinctly at 7th days compared with the fake group, which was different evidently(P0.01). The number of positive cells of the BHO group was obviously smaller than that of the model group at 4th d?7th d (P0.05), the hematoma was the biggest at 1st d, smaller at 2nd d and the smallest at 7th d. The hematoma in treatment group became smaller obviously than that did in model group at 4th d and 7th d(P0.05). Conclusion The expression of activated Caspase-3 increased obviously in the neuron around the hematoma after ICH, but BHD can markedly decrease the expression of activated Caspase-3, prohibit neuronal apoptosis, and promote the absorption of the hematoma." @default.
- W2368144620 created "2016-06-24" @default.
- W2368144620 creator A5091337748 @default.
- W2368144620 date "2006-01-01" @default.
- W2368144620 modified "2023-09-25" @default.
- W2368144620 title "Effect of Buyanhuanwu Decoction on Activated Caspase-3 after Intracerebral Hemorrhage in Rats" @default.
- W2368144620 hasPublicationYear "2006" @default.
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