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- W2368148695 abstract "Objective: To observe the ef ect of TongmafiHuazhuo Decoction(TMHZ) on mRNA and protein expression of ApoAⅠ, B in the liver of model rat with coronary heart disease, and to explore its molecular mechanism in treatment of coronary heart disease. Methods: Totally 66 clean grade SD rats were randomly divided into a normal group, model group, Xuexhikang(XZK) group, TMHZ high, medium and low dose group by weight and sex. Except for the normal group, rat models with coronary heart disease were established by using lipid infiltration calcium overload, and the lead Ⅱ ECG of the rats was recorded to test whether it was successful. After intragastric administration for 4 weeks, the rats in each group were routinely sacrificed to extract tissues. The liver mRNA and protein expression of ApoAⅠ, B were measured by RT-PCR and Western Blot, and then their expression differences were analyzed. Results: ①The mRNA and protein expression levels of ApoAI in the model group were obviously lower than those in the normal group(P0.05). Compared with the model group, mRNA and protein expression levels of ApoAI in each TMHZ treatment group and XZK group were significantly increased(P0.05, P0.01). ②The mRNA and protein expression levels of ApoB in the model group were remarkably higher than those of the normal group(P0.05, P0.01), mRNA and protein expression levels of ApoB in each TMHZ treatment group and XZK group were significantly lower than those of the model group(P0.01, P0.05). Conclusion: TMHZ is able to increase or stabilize ApoAI expression, and decrease or inhibit ApoB expression in gene and protein levels, thus increase the content of ApoAI and lower ApoB in plasma, which may be its molecular mechanisms to treat coronary heart disease, lower blood lipids, and delay the process of atherosclerosis." @default.
- W2368148695 created "2016-06-24" @default.
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- W2368148695 date "2014-01-01" @default.
- W2368148695 modified "2023-09-26" @default.
- W2368148695 title "Effect of Tongmai Huazhuo Decoction on apolipoprotein A I,apolipoprotein B gene and protein expression in model rats with coronary heart disease" @default.
- W2368148695 hasPublicationYear "2014" @default.
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