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- W2368155004 abstract "Objective:To investigate the feasibility and characteristics on model of cerebral hemorrhage induced by collagenase for injection and heparin in rats.Methods:Injecting mixed solution of collagenase(0.25 u/μl) and heparin(0.125 u/μl) 3 μl into the right caudate nucleus of rats and the same dose saline(3 μl) in the control groups.The scales of neurological behavior,volume of hematoma,histopathology were observed at 6h,24h,48h,72h,96h and 6d after injection.Results:There were no neurological defect and hematoma in the control groups.Rats in the groups receirved collagenase-heparin showed neurological defect in various degree,and the most severe change was observed after injected 24h(P0.05).The volume of hematoma reached peak at hemorrhage 24h,and most of hematoma were absorbed at 6d.There were typical changes of histopathology in hematoma area.Conclusion:Cerebral hemorrhage model in rats were eastablished by injection collagenase and heparin is ideal and reliable and the model is worth spreading because of satisfactory replication and high rate of success." @default.
- W2368155004 created "2016-06-24" @default.
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- W2368155004 date "2008-01-01" @default.
- W2368155004 modified "2023-09-23" @default.
- W2368155004 title "Investigation on model of cerebral hemorrhage induced by collagenase for injection and heparin in rats" @default.
- W2368155004 hasPublicationYear "2008" @default.
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