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- W2368156768 abstract "Objective To explore the related factors of circulating DNA level in patients with chronic HBV infection.Methods One hundred and forty-five patients with chronic HBV infection were enrolled in the study,including 30 cases with mild chronic hepatitis B,30 cases with moderate chronic hepatitis B,25 cases with severe chronic hepatitis B,30 cases with HBV-induced liver cirrhosis,30 cases with hepatocarcinoma.Thirty healthy persons were also enrolled as control.The level of plasma circular DNA was detected by duplex real-time polymerase chain reaction assay.Results As the condition of patients with chronic hepatitis B exacerbated,the level of circulating DNA increased gradually,but it reduced in patients with HBV-induced liver cirrhosis,then increased significantly in patients with hepatocarcinoma.There were significant differences among groups(P0.05).The level of circulating DNA in plasma HBeAg positive group(68.79±14.23 ng/mL) was significantly higher than that of HBeAg negative group(23.68±12.56 ng/mL)(t=2.162,P=0.032).There was a significantly positive relationship between circulating DNA and alanine aminotransferase and aspartate aminotransferase(r=0.612;0.632,P=0.014;0.021).There was no relationship between circulating DNA and HBV DNA in serum(P 0.05).Conclusion The level of circulating DNA in patients with chronic HBV infection had no relationship with viral replication,but reflects the degree of hepatocyte inflammatory necrosis." @default.
- W2368156768 created "2016-06-24" @default.
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- W2368156768 date "2013-01-01" @default.
- W2368156768 modified "2023-09-23" @default.
- W2368156768 title "Study on the related factors of circulating DNA level in patients with chronic HBV infection" @default.
- W2368156768 hasPublicationYear "2013" @default.
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