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- W2368200908 abstract "Objective To explore the therapeutic effect of herbal Euonymi Ramuli Compound(ERC) on diabetic nephropathy and its mechanism.Methods 64 Sprague-Dawleg(SD) rats were divided into normal control group,Diabetic nephropathy(DN) model group,Euonymi Ramuli Compound treatment group and Benazepril treatment group.DN model rats were prepared by intraperitoneal injection with STZ after unilateral nephrectomy.After one week,DN model rats of treatment groups were treated with Euonymi Ramuli Compound and Benazepril respectively for 12 weeks.The renal morphological changes were observed under microscopy and the ultrastructure was observedunder electron microscope.Immunohistochemical staining was performed to explore the excess expression of components of extracellular matrix in mesangial cells such as Smad4,Smad7 proteins.Immunofluorescence(IMF) was applied to unveil the immunological damage in glomerulus of kidney.HPIAS-2000 image analysis system was used for analysis of the expression of glomerular cytokines.Results Immunohistochemistry results showed that Euonymi ramuli compound and Benazepril can down-regulate the expression of Smad4 and up-regulate the expression of Smad7 in treatment groups,comparing with the model group(P 0.01).Conclusion Euonymi Ramuli Compound may exert its therapeutic effect on DN by means of down-regulation of Smad4 expression and up-regulation of Smad7 expression in DN rat kidney." @default.
- W2368200908 created "2016-06-24" @default.
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- W2368200908 date "2011-01-01" @default.
- W2368200908 modified "2023-09-26" @default.
- W2368200908 title "Effect of Euonymi Ramuli Compound on Expression of Smad4 and Smad7 in Nephridial Tissue of Rat with Diabetic Nephropathy" @default.
- W2368200908 hasPublicationYear "2011" @default.
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