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- W2368219069 abstract "Objective To study the effect of HRRG K+ channels on the invasion and migration of hepatocarcinoma(HCC) cells induced by vascular endothelial gtowth factor(VEGF).Methods The current of HRRG K+ channels in HCC line SMMC-7721 and normal liver cell line L-02 were recorded by parch camp technique.Bodyen-Chamber assays was used to monitor the VEGF-indaced invasion and migration of SMMC-7721 cells after treatment with HERG K+ channels specific inhibitor E-4031.The secretion levels of VEGF in the supematant of SMMC-7721 cells treated with E-4031 were measured by ELlSA assay.Results We recorded HERG K+current in SMMC-7721,but not in L-02 cell.In addition,we demonstrated the invasion and migration of VEGF-induced HCC cells could be dose dependently inhibited by E-4031,and the VEGF levels secreted by HCC cells were obviously decreased after HERG K+ channels blocked by E-4031.Conclusion HERG K+ current exists in the HCC cells,not in normal liver cells.Moreover,HERG K+ channels can influence the invasion and migration of HCC cells through regulating the secretion of VEGF.Therefore,the potential implications of HERG K+ channels as a new biomarker for diagnosis and prognosis of carcinogenesis,and a new pharmacological targer for liver cancer therapy are attracting increasing interest." @default.
- W2368219069 created "2016-06-24" @default.
- W2368219069 creator A5057880749 @default.
- W2368219069 date "2011-01-01" @default.
- W2368219069 modified "2023-09-23" @default.
- W2368219069 title "Effect of HERG K~+ Channels on the Invasion and Migration of Hepatocarcinoma Cells Induced by VEGF" @default.
- W2368219069 hasPublicationYear "2011" @default.
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