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- W2368219148 abstract "Objective To explore the expression of BRMS1and integrin β 1,p-AKT in ovarian cancer,and their relationships with clinicopathological features.Methods SP immanohistochemistrical method was utilized to detect the level of BRMS1,integrin β 1 and p-AKT in normal ovarian tissue,benign ovarian tumor and ovarian adenocarcinoma.Results BRMS1 positive expression in ovarian cancer was decreased(P0.01);Its expression was associated with ovarian cancer metastasis,had nothing to do with histologic grading.Integrin beta 1 and p-AKT in the positive expression rate of ovari an cancer increased(P0.01);Its expression was associated with ovarian cancer pathological staging and differentiation degree(P0.05).BRMS1 with integrin beta 1,p-AKT expressed in ovarian cancer tissue showed a negative correlation(r=-0.59,r=-0.50,P0.05).Conclusion BRMS1 might be in cooperation with integrin β 1 /p-AKT signal pathway to inhibit the metastasis function of the ovarian cancer." @default.
- W2368219148 created "2016-06-24" @default.
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- W2368219148 date "2013-01-01" @default.
- W2368219148 modified "2023-09-25" @default.
- W2368219148 title "Expression and clinical significance of BRMS1 and integrin β_1,p-AKT in ovarian carcinoma and their relationships with clinicopathological features" @default.
- W2368219148 hasPublicationYear "2013" @default.
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