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- W2368220596 abstract "Objective To explore the clinicopathological features and diagnosis of maligant meningiomas.Methods Seven cases of malignant meningiomas from the General Hospital of Beijing Military Region were studied with analysis of clinical data,MRI,pathological and immunohistochemical features,and the diagnosis and differential diagnosis were discussed with review of the literature.Results There were 3 males and 4 females with age ranging from 20 to 78 years(mean 55.9).Tumors were located in the side of cerebral falx,front and temple,anterior cranial fossa,saddle and clivus area.The clinical manifestations were tic,headache,decrescence of muscle strength and visual loss.Head MRI showed lesions with abnormal or inequable signal and obvious enhancement after contrast scan.Microscopic examination showed rhabdoid cells with middle or slight larger size,unsymmetric nuclei and red cytoplasm in 2 cases of rhabdoid meningiomas.Papillary structures with fibriovascular axis and pseudo-cauliflowering cells surrounding vessels were observed in 1 case of papillary meningioma.Cancer-like cells with high density,obvious atypia and more mitotic figures were observed in 4 cases of anaplastic meningiomas.Immunohistochemical staining showed that tumor cells were positive for EMA and vimentin in all cases and for PR in 3 cases,but negtive for PR,CD34,GFAP and CK in all cases.The Ki-67 positive cells were ranged from 14% to 57%.Conclusions Malignant meningioma is composed of rhabdoid meningioma,rhabdoid meningioma and anaplastic meningioma,which has high recurrence rate and aggressive behaviors.It is necessary to differentiate it from melanoma,atypical teratoid/rhabdoid tumor,glioma and metastatic carcinoma." @default.
- W2368220596 created "2016-06-24" @default.
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- W2368220596 date "2013-01-01" @default.
- W2368220596 modified "2023-09-26" @default.
- W2368220596 title "Malignant meningiomas:a clinicopathological analysis of 7 cases" @default.
- W2368220596 hasPublicationYear "2013" @default.
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