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- W2368230858 abstract "Objective To measure the value of plasma prethrombotic state molecular marker in early diagnosis of thrombosis in perioperation.Methods Gynecological and urological malignant tumor(not transfer) patients(n=50),benign or not tumor patients(n=20) and normal individuals(n=20).At pre-operation,post-operation 6 h,3 d and 7 d detect the leave of plasm prethrombotic state molecular marker tissue factor(TF),tissue factor pass inhibitory(TFPI),thrombus precursor protein(TpP),plasminogen activator inhibitory-1(PAI-1),P-Selectin(P-S),Thrombin-Antithrombin complexes(TAT),D-dimer(D-D) with ELISA,transmission immunity nephelometer.Results Malignant tumor patients,the levels of plasma TF,TpP,D-D in 6 h and 3 d of post-operation rose to peak value.In 7 d of post-operation the levels of TF,D-D were still higher than those of pre-operation.TpP return to pre-operation.The levels of P-S,TAT in post-operation 6 h rose to maximum,the P-S in post-operation 3 d was still on a high level.It returned to pre-operation level by 7 d after operation.The level of TAT fell to pre-operation in post-operation 3 d.TFPI and PAI-1 level in post-operation 6 h decreased,at 3 d begin rise.Higher TFPI keep near pre-operation.the levels of PAI-1 on the high side.Till in post-operation 7 d fall to pre-operation.In benign or not tumor patients,the levels of plasm TF,PAI-1 in post-operation 6 h were higher than pre-operation,other markers had not significant change.Conclusion In gynecological malignant patients and urological malignant tumor(not transfer) patients,the levels of plasma prethrombotic state molecular marker P-S,TpP and TF,D-D in post-operation 1～3 d and 1～7 d higher than in pre-operation.In benign or not tumor patients,the levels of plasma TF、PAI-1 in post-operation 6 h were higher than those in pre-operation.that indicates the body is in prethrombotic state or easy come into being prethrombotic at the moment,malignant tumors group in post-operation 6 h simutaneity PAI-1 was fall,D-D was rise namely there were primary and the secondary fibrolysis.Thus when clinic take early prevent measure must take into account whole thing in early intervetion." @default.
- W2368230858 created "2016-06-24" @default.
- W2368230858 creator A5085459827 @default.
- W2368230858 date "2008-01-01" @default.
- W2368230858 modified "2023-09-24" @default.
- W2368230858 title "APPLICATION OF PLASMA PRETHROMBOTIC STATE MOLECULAR MARKER IN EARLY DIAGNOSE OF THROMBOSIS DURING PERIOPERATION" @default.
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